Mixed crystals of insulin and insulin derivatives, a process...

Details Mixed crystals of insulin and insulin derivatives, a process... Mixed crystals of insulin and insulin derivatives, a process...

C - Chemistry, Metallurgy

07

K

530/7.4, 167/103

C07K 14/62 (2006.01) A61K 9/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1335924

Mixed crystals composed of A. unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and B. at least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin (A) and Arg-B31 human insulin and/or Arg2-(B31-32) human insulin (B) are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.

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