C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 31/728 (2006.01)
Patent
CA 2529816
The present invention relates to mixed esters of hyaluronic acid, wherein the hydroxyl groups are partially esterified with retinoic and butyric acids. These mixed esters are characterized by specific degrees of esterification and by a high ratio between the degree of substitution with butyric acid and retinoic acid. They exhibit a high anti-proliferative activity associated with activation of cell differentiation, with consequent clinical relevance in the treatment of hyper-proliferative pathologies and in particular of solid and systemic tumors.
L'invention concerne des esters mélangés d'acide hyaluronique, dans lesquels les groupes hydroxyles sont partiellement estérifiés à l'aide d'acides rétinoïques et butyriques. Ces esters mélangés se caractérisent par des degrés spécifiques d'estérification et par un rapport élevé entre le degré de substitution avec l'acide butyrique et l'acide rétinoïque. Ils présentent une activité fortement anti-proliférante associée à l'activation de la différenciation cellulaire, avec une pertinence clinique conséquente dans le traitement de pathologies hyper-proliférantes et en particulier de tumeurs solides et systémiques.
Coradini Danila
Perbellini Alberto
Bereskin & Parr
Sintofarm S.p.a.
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