C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/119, 167/46,
C07F 3/00 (2006.01) C07F 15/00 (2006.01) C07H 21/00 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2002380
MIXED LIGAND COMPLEXES AND USES THEREOF AS BINDING AGENTS TO DNA Abstract of the Disclosure This invention concerns a coordination complex or salt thereof which is spectroscopically or photoactively determinable when bound to DNA having the formula Image , wherein M is a suitable transition metal and each of R1, R2 and R3 is ethylenediamine, bipyridine, phenanthroline, diazafluorene-9-one or a substituted derivative thereof, or phenanthrenequinonediimine or a substituted derivative thereof, dypyridophenazine or a substituted derivative thereof; wherein R1, R2 and R3 are bound to M by coordination bonds; provided that at least one of R1, R2 or R3 is dypyridophenazine or a substituted derivative thereof. The invention also concerns a labeled DNA probe which comprises the complex covalently bound to the DNA probe. Further the invention concerns a method of detecting the presence in a sample a target DNA of interest which comprises contacting the sample containing the target DNA with a complementary labeled DNA probe under hybridizing conditions and measuring the resulting luminescence emmited from the labeled DNA probe, a change in the luminescense as compared with the luminescense in the absence of the sample indicating the prescence of the target DNA.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
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