C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 1/00 (2006.01) A61K 31/28 (2006.01) A61K 31/30 (2006.01) A61K 31/315 (2006.01) A61K 31/44 (2006.01) A61K 31/555 (2006.01) C07F 3/00 (2006.01) C07F 5/00 (2006.01) C07F 7/00 (2006.01) C07F 9/00 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07F 19/00 (2006.01)
Patent
CA 2132847
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M)x'x(L)y(R1R2N-N2O2)2], and M is a pharmaceutically acceptable metal, or where x is at least two, M may be a mixture of two different pharmaceutically acceptable metals; L is a ligand, different from (R1R2N-N2O2), and is bound to at least one metal; R1 and R2 are each organic moieties and may be the same or different; x is an integer of from 1 to 10, inclusive; x' is the formal oxidation state of the metal M, and is an integer of from 1 to 6 inclusive; y is an integer of from 1 to 18; inclusive, and where y is at least two, L may be the same ligand or a mixture of different ligands. z is an integer of from 1 to 20, inclusive; provided that where M is copper, x is one, L is methanol and y is one, that at least one of R1 or R2 is not ethyl; and K is a pharmaceutically acceptable counterion present in the composition when the overall charge of A is not zero counterion K being present only in an amount to neutralize A. Methods of treating mammals with such compounds are provided. Pharmaceutical compositions containing such compounds are also provided.
Christodoulou Danae D.
Keefer Larry K.
Wink David A. Jr.
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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