Mixed lineage kinases and metabolic disorders

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/553 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2693694

Methods of treating metabolic stress disorders are disclosed that include administering to a subject a therapeutically effective amount of a composition that specifically inhibits the expression or activity of a mixed lineage kinase (MLK). Also disclosed are methods of identifying candidate compounds for treatment of metabolic stress disorders and methods of diagnosing metabolic stress disorders.

L'invention concerne des méthodes de traitement de troubles métaboliques liés au stress, qui comprennent l'administration à un sujet d'une quantité thérapeutiquement efficace d'une composition inhibant spécifiquement l'expression ou l'activité d'une kinase de lignée mixte (MLK). L'invention concerne aussi des procédés d'identification de composés candidats pour le traitement de troubles métaboliques liés au stress et des procédés de diagnostic de tels troubles.

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