Mixed metal compounds for treatment of hyperphos phataemia

A - Human Necessities – 61 – K

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A61K 33/26 (2006.01) C01G 49/00 (2006.01)

Patent

CA 2699576

The present invention relates to mixed metal compounds having pharmaceutical activity, especially as phosphate binders. It also extends to methods of manufacture of those compounds, as well as to pharmaceutical compositions containing such compounds. It further relates to their pharmaceutical use. In particular, the present invention relates to use of compounds of Formula (I). M11 1-a M111a wherein M is at least one bivalent metal (i.e. with two positive charges); M1 is at least one trivalent metal (i.e. with three positive charges); and 1 > a > 0.4.

La présente invention porte sur des composés métalliques mixtes ayant une activité pharmaceutique, notamment en tant que liants de phosphate. L'invention porte également sur des procédés de fabrication de ces composés, ainsi que sur des compositions pharmaceutiques contenant de tels composés. Elle porte en outre sur leur utilisation pharmaceutique. En particulier, la présente invention porte sur l'utilisation de composés représentés par la Formule (I) : Mll 1-a Mlll a, dans laquelle M' est au moins un métal bivalent (à savoir avec deux charges positives ) ; M1' est au moins un métal trivalent (à savoir avec trois charges positives) ; et 1 > a > 0,4.

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