Mixed orl1/mu-agonists for the treatment of pain

Details Mixed orl1/mu-agonists for the treatment of pain Mixed orl1/mu-agonists for the treatment of pain

A - Human Necessities

61

K

A61K 31/407 (2006.01) A61K 31/438 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2664702

The invention relates to the use of compounds having an affinity for the µ opioid receptor of at least 100 nM (Ki human value) and an affinity for the ORL-1 receptor for producing a medicament for treating pain, the ratio between the ORL1/µ affinities defined as 1/[Ki(ORL1)/Ki(µ)] being between 0.1 and 30.

L'invention concerne l'utilisation de composés qui présentent une affinité pour le récepteur opioïde µ d'au moins 100 nM (valeur Ki chez l'homme) et une affinité pour le récepteur ORL-1 pour produire un médicament contre la douleur, le rapport entre les affinités ORL1/µ représenté par 1/[Ki(ORL1)/Ki(µ)] étant compris entre 0,1 et 30.

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