Mixture having antitumor activities

Details Mixture having antitumor activities Mixture having antitumor activities

C - Chemistry, Metallurgy

12

P

C12P 19/04 (2006.01) A61K 31/715 (2006.01) C08B 37/00 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2160082

A purified hot-water extract from Mycobacterium bovis (BCG vaccine) has been found to have significant antitumor activity against a mouse bladder tumor model and a murine sarcoma in vivo, but not in vitro. The material, termed PS1A1, has an approximate molecular weight of between 60 and 90 kDa, is freely soluble in water, but has low solubility in acetone or ethanol, and is remarkably heat-stable.

On a découvert qu'un extrait obtenu dans l'eau chaude et purifié de Mycobacterium bovis (vaccin BCG) exerce une activité antitumorale importante sur un modèle de tumeur de la vessie de souris et sur un sarcome de la souris in vivo, mais non in vitro. Le matériel appelé PS1A1 a un poids moléculaire approximatif variant entre 60 et 90 kDa, est librement soluble dans l'eau, mais faiblement soluble dans l'acétone et se distingue par sa remarquable stabilité à la chaleur.

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