Mixture of antibiotics produced by a species of actinoplanes

Details Mixture of antibiotics produced by a species of actinoplanes Mixture of antibiotics produced by a species of actinoplanes

C - Chemistry, Metallurgy

12

P

195/89, 530/15.0

C12P 1/00 (2006.01) C07G 11/00 (2006.01)

Patent

CA 1045568

ABSTRACT OF THE DISCLOSURE A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.

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