A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) C07K 14/025 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2446062
The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.
Mélange de peptides issus des protéines E6 et/ou E7 d'un papillomavirus impliqué dans le cancer du col de l'utérus, tel que HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57 et HPV58, par exemple ainsi que ses applications en tant que médicament (dans des compositions immunogènes, aptes à stimuler la production de lymphocytes T CD4+ anti-HPV in vivo et donc utiles pour la vaccination contre les cancers du col de l'utérus et dans d'autres cancers) ou en tant que réactif de diagnostic de lymphocytes T spécifiques d'un HPV, notamment pour évaluer l'état immunitaire des patients. Mélange de peptides issus des protéines E6 et/ou E7 d'un papillomavirus impliqué dans des lésions bénignes de la peau (verrues par exemple), tel que HPV10, HPV3 ou HPV4 et ses applications en tant que médicament.
Bourgault-Villada Isabelle
Guillet Jean-Gerard
Maillere Bernard
Pouvelle-Moratille Sandra
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