C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/18 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) A61P 31/14 (2006.01) C12N 15/51 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) G01N 33/80 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2495456
The invention relates to a peptide mixture including at least two different peptides from the hepatitis C virus (HCV), whereby at least one of them is a peptide from the C protein binding to at least four different HLA-II molecules, the occurrence of which exceeds 5 % in the Caucasian population with a binding activity < 1,000 nM. Said invention also relates to the applications thereof as a drug useful in the prevention and treatment of HCV infections or as a diagnostic reagent for HCV-specific T lymphocytes.
Mélange de peptides incluant au moins deux peptides différents issus du virus de l'hépatite C (VHC), dont l'un au moins est un peptide issu de la protéine C, se liant à au moins quatre molécules HLA II différentes dont la fréquence est supérieure à 5 % dans la population caucasienne, avec une activité de liaison < 1000 nM, et ses applications en tant que médicament utile pour la prévention et le traitement des infections à VHC ou en tant que réactif de diagnostic de lymphocytes T spécifiques du VHC.
Bouzidi Ahmed
Castelli Florence
Georges Bertrand
Maillere Bernard
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