Mixtures of calcitonin drug-oligomer conjugates comprising...

Details Mixtures of calcitonin drug-oligomer conjugates comprising... Mixtures of calcitonin drug-oligomer conjugates comprising...

A - Human Necessities

61

K

A61K 38/23 (2006.01) A61K 47/48 (2006.01) C07K 14/585 (2006.01)

Patent

CA 2449686

A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non- conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin.

L'invention concerne un mélange de conjugués dans lequel chaque conjugué comprend un médicament à base de calcitonine couplé à un oligomère comprenant une fraction de polyalkylène glycol. Ce mélange peut baisser le taux de calcium sérique par 10, 15 ou même 20 % ou plus, chez un sujet. Par ailleurs, ce mélange peut mieux survivre à la digestion intestinale dans un modèle in vitro qu'une calcitonine non conjuguée. De plus, ce mélange peut présenter une biodisponibilité plus élevée que la calcitonine non conjuguée.

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