A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/28 (2006.01) A61K 38/00 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) A61K 47/48 (2006.01) A61P 5/50 (2006.01)
Patent
CA 2449426
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.
L'invention concerne un mélange de conjugués dans lequel chaque conjugué comprend un médicament à base d'insuline couplé à un oligomère comprenant une fraction de polyalkylène glycol. Ce mélange peut avoir une activité in vivo plus importante que celle d'un mélange polydispersé de conjugués similaires. De plus, ce mélange peut mieux survivre à la digestion intestinale dans un modèle in vitro que des mélanges polydispersés de conjugués similaires. Ce mélange peut également présenter une plus faible variabilité entre les sujets que les mélanges polydispersés de conjugués similaires.
Ansari Aslam M.
Ekwuribe Nnochiri N.
Odenbaugh Amy L.
Price Christopher H.
Radhakrishnan Balasingam
Biocon Limited
Nobex Corporation
Sim & Mcburney
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