Ml-236b derivatives and their preparation

Details Ml-236b derivatives and their preparation Ml-236b derivatives and their preparation

C - Chemistry, Metallurgy

07

C

195/131, 260/357

C07C 69/732 (2006.01) C07D 309/30 (2006.01) C12P 7/42 (2006.01) C12P 7/62 (2006.01) C12P 17/06 (2006.01)

Patent

CA 1150170

Abstract the disclosure Compounds of formula (I): Image (I) (wherein R represents d group of formula Image or Image and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C1-C5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalosporum and Streptomyces, or cell- free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.

379232

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