Mmp-2 and/or mmp-9 inhibitor

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4439 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2718005

The present invention provides a highly safe pharmaceutical preparation effective for diseases caused by MMP-2 and/or MMP-9. The pharmaceutical preparation contains, as an active ingredient, at least one member selected from the group consisting of thiazole derivatives represented by Formula (1): wherein R1 represents a phenyl group that may have 1 to 3 lower alkoxy groups as substituents on the phenyl ring, and R2 represents a pyridyl group that may have 1 to 3 carboxyl groups as substituents on the pyridine ring, and salts thereof. Such thiazole derivatives have MMP-2 and/or MMP-9 inhibitory activity.

La présente invention porte sur une préparation pharmaceutique hautement sûre, efficace pour des maladies provoquées par MMP-2 et/ou MMP-9. La préparation pharmaceutique contient, en tant que principe actif, au moins un élément choisi dans le groupe constitué par les dérivés de thiazole représentés par la Formule (1) : dans laquelle R1 représente un groupe phényle qui peut avoir de 1 à 3 groupes alcoxy inférieurs en tant que substituants sur le cycle phényle, et R2 représente un groupe pyridyle qui peut avoir de 1 à 3 groupes carboxyle en tant que substituants sur le cycle pyridine, et les sels de ces dérivés. De tels dérivés de thiazole ont une activité inhibitrice en ce qui concerne MMP-2 et/ou MMP-9.

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