Mntf differentiation and growth of stem cells

Details Mntf differentiation and growth of stem cells Mntf differentiation and growth of stem cells

A - Human Necessities

61

K

A61K 38/17 (2006.01)

Patent

CA 2626728

The present invention provides methods for inducing differentiation of an embryonic stem cell into a motor neuron using a motoneuronotrophic factor (MNTF) or its peptide analogues. The present invention further provides a method for isolating a population of stem cell derived motor neurons and a population of cells comprising the differentiated neural cells. Additionally, the present invention is directed to a method of enhancing the survival of the differentiated neural cells in long term cell cultures. Finally, the present invention provides compositions containing MNTF or its peptide analogs for therapeutic use in conjunction with stem cells.

L'invention concerne des méthodes pour induire une différenciation de cellules souches embryonnaires en motoneurone, à l'aide d'un facteur motoneuronotrophique (MNTF) ou de ses analogues peptidiques. L'invention concerne également une méthode pour isoler une population de motoneurones dérivés de cellules souches et une population de cellules comprenant les cellules neurales différenciées. En outre, l'invention concerne une méthode d'amélioration de la survie des cellules neurales différenciées, dans des cultures cellulaires à long terme. Enfin, l'invention concerne des compositions contenant MNTF et ses analogues peptidiques, lesquelles compositions étant destinées à une utilisation thérapeutique associée à des cellules souches.

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