Modafinil compositions

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 317/28 (2006.01)

Patent

CA 2534664

Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modulated to improve efficacy in pharmaceutical compositions.

L'invention porte sur la formation de co-cristaux et de solvates de modafinil racémique, énantiomériquement pur, et énantiomériquement mixte et sur la modulation de plusieurs de leurs propriétés physiques importantes. La solubilité, la dissolution, la biodisponibilité, la relation dose-effet et la stabilité du modafinil peuvent modulées pour améliorer l'efficacité des compositions pharmaceutiques.

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