Model epithelial cell cultures

Details Model epithelial cell cultures Model epithelial cell cultures

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 31/403 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2447824

In one aspect, the invention provides cell cultures and culture conditions that facilitate the establishment of an intestinal epithelial cell culture that has characteristics of the intestinal epithelium, such as: transepithelial electrical resistance, enzyme expression and microvilli morphology. Cell cultures of the invention may use fatty acids such as sodium butyrate and kinase modulators such as 2-{1-[3-(amidinothio)propyl]-1H-indol-3-yl}-3-(1- meethylindol-3- yl)-maleimide methanesulfonate.

Dans un aspect, l'invention concerne des cultures cellulaires et des conditions de culture permettant de faciliter la réalisation d'une culture de cellules épithéliales intestinales présentant les caractéristiques de l'épithélium intestinal, telles que la résistance électrique transépithéliale, l'expression enzymatique et la morphologie microvillositaire. Les cultures cellulaires de l'invention peuvent utiliser des acides gras tels que le butyrate de sodium et des modulateurs de kinases tels que le 2-{1-[3-(amidinothio)propyl]-1H-indol-3-yl}-3-(1-méthylindol-3-yl)-maléimide méthanesulfonate.

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