C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/26 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2339581
The present invention is directed to the use of computational and other experimental data in the design of new pharmaceuticals, and in predicting the metabolism and toxicological profiles thereof. Computational and other information is used to further understand drug metabolism and toxicology, particulary in relation to monooxygenase enzymes, such as those of the CYP system, that are involved in drug metabolism. Information derived according to the practice of the invention is useful in determining the clearance or half- life of drugs, and the nature and toxicity of byproducts resulting from their metabolism. The invention provides novel and powerful new approaches to drug design.
La présente invention concerne l'utilisation de données de calcul et d'autres données expérimentales pour la conception de nouveaux produits pharmaceutiques, et pour la prédiction de leur profils métabolique et toxicologique. On utilise des informations de calcul et d'autres informations pour mieux comprendre le métabolisme et la toxicologie de médicaments, notamment par rapport à des enzymes monooxygénase, telles que celles du système du cytochrome P-450 (CYP) qui interviennent dans le métabolisme des médicaments. Les informations obtenues par application de la présente invention sont utiles pour déterminer l'autorisation de mise en circulation et la demi-vie de médicaments, ainsi que la nature et la toxicité de produits dérivés découlant de leur métabolisme. L'invention concerne des méthodes nouvelles et fondamentales de conception de médicaments.
Higgins Leeann
Jones Jeffrey P.
Korzekwa Kenneth R.
Cassan Maclean
University Of Pittsburgh
University Of Rochester
LandOfFree
Modelling organic compound reactivity in cytochrome p450... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modelling organic compound reactivity in cytochrome p450..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modelling organic compound reactivity in cytochrome p450... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1623439