C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01K 67/027 (2006.01) A61K 31/435 (2006.01) A61K 31/436 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/58 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2306448
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca++ stimulation of the hypertrophic response is mediated through NF-AT3. Thus, the present invention provides methods of treating cardiac hypertrophy as well as transgenic constructs for preparing transgenic animals. Further provided are methods of using the transgenic animals of the present invention, or cells isolated therefrom, for the detection of compounds having therapeutic activity toward cardiac hypertrophy.
La présente invention concerne l'hypertrophie cardiaque. Plus particulièrement, la présente invention définit les évènements moléculaires liant une stimulation calcique à l'hypertrophie cardiaque. Plus spécifiquement, la présente invention montre que la stimulation Ca?++¿ de la réponse hypertrophique est induite par NF-AT3. Ainsi, la présente invention présente des méthodes de traitement de l'hypertrophie cardiaque ainsi que des constructions transgéniques permettant la préparation d'animaux transgéniques. En outre, l'invention concerne des méthodes d'utilisation des animaux transgéniques de la présente invention, ou de cellules isolées de ceux-ci, pour la détection de composés présentant une activité thérapeutique sur l'hypertrophie cardiaque.
Grant Stephen R.
Molkentin Jeffrey D.
Olson Eric N.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
University Of North Texas Health Science Center At Forth Worth
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