Models of chronic and acute inflammatory diseases

Details Models of chronic and acute inflammatory diseases Models of chronic and acute inflammatory diseases

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 67/027 (2006.01) C12N 15/00 (2006.01) G01N 33/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2408409

Methods and compositions are provided for the creation and screening of non- human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of immunocompetent effector cells, depleted of CD25+ T cells. The effector cells are tolerant of the host major histocompatibility antigens, but reactive to at least one antigen present in the host animal. The transferred cells are preferably stimulated and localized by administration of an immunostimulant at a local site. The animals are useful for a variety of screening assays and for investigation into disease causes and pathways. A variety of chronic inflammatory diseases may be studied with this model, including psoriasis, rheumatoid arthritis, diabetes, inflammatory bowel disease and multiple sclerosis.

L'invention concerne des procédés et des compositions servant à la création et au criblage de modèles animaux non humains souffrant d'inflammations chroniques. Les animaux hôtes immunodéprimés se voient injecter une population de cellules effectrices immunocompétentes, extraites de lymphocytes T CD25+. Les cellules effectrices tolèrent la plupart des antigènes histocompatibles de l'hôte, mais réagissent à au moins un antigène présent chez l'animal hôte. Les cellules transférées sont de préférence stimulées et localisées par l'administration d'un immunostimulant à un site local. Les animaux sont utiles dans diverses analyses de criblage et dans la recherche dans le domaine des causes et des voies des maladies. Diverses maladies inflammatoires chroniques peuvent être étudiées avec ce modèle, dont le psoriasis, l'arthrite rhumatoïde, le diabète, la maladie inflammatoire intestinale et la sclérose en plaques.

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