Models of thrombotic thrombocytopenic purpura and methods of...

Details Models of thrombotic thrombocytopenic purpura and methods of... Models of thrombotic thrombocytopenic purpura and methods of...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2741634

The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)- like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.

La présente invention concerne le développement dun modèle animal pour soumettre à essai différents agents dans le traitement dun trouble de la coagulation. Plus spécifiquement, linvention concerne lutilisation de multimères de poids moléculaire très élevé de facteur de von Willebrand (VWF) dans différentes souches de souris pour induire des symptômes de type purpura thrombopénique thrombotique (TTP) pour le développement dun modèle chez la souris de TTP. Linvention concerne en outre des procédés pour générer de tels modèles de maladie chez lanimal et des procédés de criblage pour identifier des composés biologiquement actifs qui sont efficaces dans le traitement de TTP.

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