Modification of allergens for immunotherapy

Details Modification of allergens for immunotherapy Modification of allergens for immunotherapy

A - Human Necessities

61

K

A61K 39/35 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2729151

The present invention relates to pharmaceutical compositions for immunotherapy, for example for immunotherapy of peanut allergy. Further, the present invention relates to methods for the preparation of the present pharmaceutical compositions for immunotherapy, and their use in immunotherapy. Furthermore, the present invention relates to processes for modifying allergens thereby enhancing their application in immunotherapy. The invention also relates to the present modified allergens and pharmaceutical compositions comprising the present allergens, as well as to the use thereof in immunotherapy. According to a particu-larly preferred embodiment, the present invention relates to pharmaceutical compositions for immunotherapy comprising reduced and alkylated naturally occurring peanut allergens Ara h2 and/or Ara h6, or derivates or isoforms thereof wherein said pharmaceu-tical composition substantially does not comprise Ara h1 and/or Ara h3.

La présente invention concerne des compositions pharmaceutiques pour l'immunothérapie, par exemple pour l'immunothérapie de l'allergie à l'arachide. De plus, la présente invention concerne des procédés pour la préparation des présentes compositions pharmaceutiques pour l'immunothérapie, et leur utilisation en immunothérapie. De plus, la présente invention concerne des procédés pour modifier des allergènes de manière à améliorer leur application en immunothérapie. L'invention concerne en outre les présents allergènes modifiés et des compositions pharmaceutiques comprenant les présents allergènes, ainsi que l'utilisation de ceux-ci en immunothérapie. Selon un mode de réalisation particulièrement préféré, la présente invention concerne des compositions pharmaceutiques pour immunothérapie comprenant des allergènes d'arachide d'origine naturelle réduits et alkylés Ara h2 et/ou Ara h6, ou des dérivés ou des isoformes de ceux-ci, ladite composition pharmaceutique ne contenant sensiblement pas Ara h1 et/ou Ara h3.

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