Modification of amyloid-beta load in non-brain tissue

Details Modification of amyloid-beta load in non-brain tissue Modification of amyloid-beta load in non-brain tissue

G - Physics

01

N

G01N 33/50 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2742771

The present invention relates to methods and compositions for modulating levels of amyloid-.beta. peptide (A.beta.) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of A.beta. levels via selective modulation (e.g., inhibition) of .gamma.-secretase activity. The invention also relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an A.beta.-related disorder, by administering a compound that result in the modulation of .gamma.-secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain A.beta. disorder, such as Alzheimer's disease.

La présente invention concerne des procédés et des compositions pour moduler des taux de peptide amyloïde-ß (Aß) présentés par des cellules, fluides ou tissus non neuronaux (cest-à-dire, périphériques). Linvention concerne en outre la modulation de taux de Aß par modulation sélective (par exemple, inhibition) dactivité ?-sécrétase. Linvention concerne en outre des procédés de prévention, traitement ou amélioration des symptômes dun trouble, comprenant, mais non limité à un trouble associé à Aß, par administration dun composé qui conduit à la modulation de ?-sécrétase dans un tissu non neuronal, directement ou indirectement pour prévenir, traiter ou améliorer les symptômes dun trouble cérébral associé à Aß, tel que la maladie dAlzheimer.

Affiliated with

Also associated with

Rating

Modification of amyloid-beta load in non-brain tissue does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modification of amyloid-beta load in non-brain tissue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modification of amyloid-beta load in non-brain tissue will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1607495