Modification of clostridial toxins for use as transport...

Details Modification of clostridial toxins for use as transport... Modification of clostridial toxins for use as transport...

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191754

A chemical conjugate for treating a nerve cell related disorder is provided. This conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is conjugated to a drug or other bioactive molecule without affecting the toxin's ability to enter the target nerve cell.

Un produit de conjugaison chimique permet de traiter une affection liée aux cellules nerveuses. Il comprend une toxine de Clostridium, active ou non, présentant une spécificité pour une cellule nerveuse cible. Cette toxine est conjuguée à un médicament ou à une autre molécule bioactive, sans que cela l'empêche d'entrer dans la cellule nerveuse cible.

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