Modification of cxcr4 using engineered zinc finger proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/22 (2006.01) A61K 35/12 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/55 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2755192

Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc fmger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.

La présente invention concerne des procédés et des compositions pour moduler l'activité de gènes CXCR4, par exemple en utilisant des facteurs de transcription à doigt de zinc (ZF-TF) ou des nucléases à doigt de zinc (ZFN) comprenant une protéine à doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. La présente invention concerne en outre des polynucléotides codant pour des ZF-TF ou des ZFN, des vecteurs comprenant des polynucléotides codant pour des ZF-TF ou des ZFN et des cellules comprenant des polynucléotides codant pour des ZF-TF ou des ZFN et/ou des cellules comprenant des ZF-TF ou des ZFN.

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