Modification of endogenous circadian pacemaker

Details Modification of endogenous circadian pacemaker Modification of endogenous circadian pacemaker

A - Human Necessities

61

N

A61N 5/06 (2006.01) A61M 21/00 (2006.01)

Patent

CA 2062718

2062718 9015639 PCTABS00002 A method for assessing and modifying the phase and amplitude of the endogenous circadian pacemaker in treating "jet lag" sufferers, shift workers, advanced circadian phase experienced by elderly subjects, and those with delayed sleep phase insomnia. A circadian cycle modification capacity assessment method comprises eliminating activity-related factors associated with the sleep-rest cycle which mask the state of the endogenous circadian pacemaker. Based on either individual or normative assessment data, the circadian phase and amplitude modification method involves application of bright light, and episodes of imposed darkness, at chosen phases. Timing of episodes of bright light by reference to a mathematical model in which the endogenous circadian pacemaker is a second order differential equation. A forcing function in the model is proportional to changes in the cube root of surrounding illuminance. Amplitude of the endogenous circadian pacemaker may be reduced to modify phase.

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