Modification of hepatitis b core antigen

Details Modification of hepatitis b core antigen Modification of hepatitis b core antigen

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61P 31/20 (2006.01) C07K 14/02 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2413546

A protein is provided comprising hepatitis B core antigen (HBcAg) wherein one or more of the four arginine repeats has been deleted, said protein comprising the C-terminal cysteine of HBcAg. The deleted region may be replaced by an epitope from a protein other than HBcAg, in which case the HBcAg acts as a carrier to present the epitope to the immune system. The chimeric protein is useful in prophylactic and therapeutic vaccination of a host, for example against hepatitis B virus.

L'invention concerne une protéine qui comprend l'antigène capsidique de l'hépatite B (HBcAg) et dans laquelle on a supprimé au moins l'une des quatre répétitions arginine, cette protéine comprenant en outre la cystéine C-terminale de HBcAg. La région supprimée peut être remplacée par un épitope provenant d'une protéine autre que HBcAg, auquel cas HBcAg agit en tant que support pour présenter l'épitope au système immun. La protéine chimère est utile dans la vaccination prophylactique et thérapeutique d'un hôte, par exemple contre le virus de l'hépatite B.

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