Modification of interferon alpha production

Details Modification of interferon alpha production Modification of interferon alpha production

C - Chemistry, Metallurgy

07

K

C07K 14/56 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2354025

A process for the production of .alpha.-interferon comprising the steps: i) inducing of human leukocytes by means of a virus; ii) treating the leukocytes with an enhancing agent selected from: a) Xanthine, pyrimidinol and pyrimidinone or derivatives of anyone thereof, such as theophylline, 2-amino-5- bromo-6-methyl-4 pyriminidol or thymine; b) an organic solvent selected from the group consisting of non-aromatic ketones, aliphatic or cyclic amides, alkylated aliphatic or cyclic urea derivatives and aliphatic or cyclic sulfoxides, such as N-methyl-2-pyrrolidinone, acetone, 2-butanone, 1,3- dimethyl-2-imidazolidinone, dimethylsulfoxide, 4-methyl-2-pentanone-N-ethyl-2- pyrrolidinone, 2-pyrrolidinone, tetramethylene sulfoxide or N,N,- dimethylacetamide; or a combination of the compounds from a) with an organic solvent from b).

L'invention concerne un procédé de production d'interféron .alpha., consistant à : i) induire des leucocytes humains à l'aide d'un virus ; ii) à traiter ces leucocytes avec un agent stimulant choisi parmi a) xanthine, pyrimidinol, pyrimidinone ou leurs dérivés tels que théophylline, 2-amino-5-bromo-6-méthyl-4 pyrimidinol ou thymine ; b) un solvant organique choisi dans le groupe constitué des cétones non aromatiques, des amides aliphatiques ou cycliques, des dérivés aliphatiques ou cycliques alkylés de l'urée et des sulfoxydes aliphatiques ou cycliques tels que N-méthyl-2-pyrrolidinone, acétone, 2-butanone, 1,3-diméthyl-2-imidazolidinone, diméthylsulfoxyde, 4-méthyl-2-pentanone-N-éthyl-2-pyrrolidinone, 2-pyrrolidinone, tétraméthylène sulfoxyde ou N,N,-diméthylacétamide ; ou une combinaison des composés du groupe a) et d'un solvant organique du groupe b).

Affiliated with

Also associated with

Rating

Modification of interferon alpha production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modification of interferon alpha production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modification of interferon alpha production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1590523