Modification of nucleic acid vectors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2744938

The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer comprises one or more positively charged quaternary amino groups, wherein the nucleic acid vector is a micro-organism selected from the group consisting of a virus, a bacteria or a bacteriophage, a fungus, a spore, a eukaryotic cell nucleus or other micro-organism fragment or a component containing genetic information, and wherein (a) the polymer and/or the linkages between it and the nucleic acid vector are hydrolytically, reducibly or enzymatically degradable; and/ or (b) wherein each of the positively charged quaternary amino groups is linked to the polymer backbone via one or more degradable or biodegradable linkages.

L'invention concerne un vecteur d'acide nucléique modifié polymère dans lequel le vecteur d'acide nucléique est lié de manière covalente à un polymère; ledit polymère comprend au moins un groupe aminé quaternaire chargé positivement, le vecteur d'acide nucléique étant un microorganisme choisi dans le groupe constitué d'un virus, d'une bactérie ou d'un bactériophage, d'un champignon, d'une spore, d'un noyau de cellule eucaryote ou autre fragment de microorganisme ou d'un composant contenant des informations génétiques, et, en outre, (a) le polymère et/ou les liens entre lui et le vecteur d'acide nucléique sont dégradables d'une manière hydrolytique, réductible ou enzymatique; et/ou (b) chacun des groupes aminés quaternaires chargés positivement est lié au squelette du polymère par le biais d'un ou de plusieurs liens dégradables ou biodégradables.

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