Modification of protein glycosylation in methylotrophic yeast

Details Modification of protein glycosylation in methylotrophic yeast Modification of protein glycosylation in methylotrophic yeast

C - Chemistry, Metallurgy

12

N

C12N 1/16 (2006.01) C07K 14/00 (2006.01) C12N 15/81 (2006.01)

Patent

CA 2545693

The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.

La présente invention a trait à des procédés et des souches de levure méthylotrophique génétiquement modifiées pour la production de glycoprotéines assimilée à la glycosylation mammalienne. La présente invention a également trait à des vecteurs utiles pour la génération de souches de levure méthylotrophique aptes à la production de glycoprotéines assimilée à la glycosylation mammalienne. L'invention a trait en outre à des glycoprotéines produites à partir de souches de levure méthylotrophique génétiquement modifiées.

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