Modification of rna, producing an increased transcript...

Details Modification of rna, producing an increased transcript... Modification of rna, producing an increased transcript...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2621444

The invention relates to the stabilisation of RNA, in particular mRNA and to the increased translation of mRNA. The invention specifically relates to three modifications of RNA, in particular in vitro transcribed RNA, which produce an increased transcript stability and translation efficiency.

L'invention concerne la stabilisation d'ARN, en particulier d'ARNm, et une augmentation de la translation d'ARNm. L'invention concerne, en particulier, trois modifications d'ARN, en particulier d'ARN transcrit in vitro, qui entraînent une capacité de transcription et une efficacité de translation améliorées.

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