Modification of the sustained release profile

Details Modification of the sustained release profile Modification of the sustained release profile

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/335 (2006.01) A61K 31/663 (2006.01) A61K 31/7088 (2006.01) A61K 38/02 (2006.01) A61K 38/18 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2444421

The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the biologically active agent incorporated therein, and a bisphosphonate wherein the bisphosphonate compound is present in an amount sufficient to modify the release profile of the biologically active agent from the sustained release composition. Pharmaceutical compositions suitable for use in the method of the invention are also disclosed.

La présente invention concerne une méthode destinée à la libération prolongée in vivo d'un agent biologiquement actif. Cette méthode consiste à administrer à un sujet nécessitant un tel traitement une dose efficace d'une composition à libération prolongée comprenant un polymère biocompatible renfermant cet agent biologiquement actif ainsi qu'un composé de bisphosphonate, ce composé étant présent en concentration suffisante pour modifier le profil de libération de l'agent biologiquement actif à partir de la composition à libération prolongée. L'invention concerne également des compositions pharmaceutiques pouvant être utilisées dans la méthode susmentionnée.

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