Modifications of somatotropins for enhanced stability

Details Modifications of somatotropins for enhanced stability Modifications of somatotropins for enhanced stability

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01)

Patent

CA 1340122

The present invention discloses variant somatotropins in which the asparagine located between positions 95-101 of a mammalian somatotropin are replaced by glutamine. Such somatotropins exhibit enhanced stability and are useful for enhancing the growth of mammals and for increasing milk production in a female mammal. Also disclosed is a DNA sequence coding for a mammalian somatotropin in which the codon for asparagine located between positions 95-101 of somatotropin is replaced by a codon for glutamine.

609518

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