Modified...

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C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) A61K 31/70 (2006.01) A61P 31/18 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C07H 15/04 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2158534

Human immunodeficiency viruses (HIV-I and HIV-2) are known to be the etiological agents of acquired immunodeficiency syndrome (AIDS). The carbohydrate structures on the virus coat proteins, gp120, are necessary for cell-cell fusion. the oligosaccharides on gp120 are processed by the enzyme glycosidase. The trisaccharide, .alpha.-D-Glcp-(1-2)-.alpha.-D-Glcp-(1-3)-.alpha.-D- GlcpO(CH2)8COOMe and its analogues modified at its terminal glucose residues are recognized by the enzyme and can inhibit glycosylation.

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