C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/06 (2006.01) A61K 31/7056 (2006.01) A61K 31/706 (2006.01) A61K 31/7064 (2006.01) A61K 31/7076 (2006.01) A61P 31/14 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01) C07H 19/044 (2006.01) C07H 19/048 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01) C07H 19/10 (2006.01) C07H 19/12 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 19/22 (2006.01) C07H 19/23 (2006.01)
Patent
CA 2490191
2' and/or 3' prodrugs of l', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treatFlaviviridae infections and other related conditions.
Promédicaments 2' et/ou 3' de nucléosides à branches 1', 2', 3' ou 4' ainsi que leurs sels pharmaceutiquement acceptables et leurs dérivés. Ces promédicaments sont utiles dans la prévention et le traitement des infections par les flavivirus, y compris l'infection par le virus de l'hépatite C et d'autres états liés à ces maladies. L'invention comprend une description des composés et des compositions de ces promédicaments, ainsi que des procédés et de l'utilisation, y compris l'administration d'une quantité efficace de promédicaments de l'invention ou de leurs sels ou dérivés efficaces. Ces médicaments peuvent éventuellement être administrés en combinaison ou en alternance avec d'autres agents antiviraux, à des fins de prévention ou de traitement des infections aux flavivivirus et d'autres états qui y sont liés.
Gosselin Gilles
La Colla Paolo
Sommadossi Jean-Pierre
Storer Richard
Centre National de La Recherche Scientifique
Idenix (cayman) Limited
Idenix Pharmaceuticals Inc.
L'universite Montpellier II
Mbm Intellectual Property Law Llp
LandOfFree
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