C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2263281
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
L'invention concerne un procédé de modification de la longueur de chaîne et des spécificités de position de liaison double d'une désaturase d'acide gras végétal soluble. Plus précisément, ledit procédé consiste à modifier les restes de contact d'acides aminés, qui sont au contact de l'acide gras, dans le canal de liaison du substrat de la désaturase de l'acide gras soluble. L'invention porte plus spécifiquement sur la modification d'une acyl-ACP désaturase. Les restes de contact d'acides aminés qui se trouvent dans le canal de liaison du substrat sont identifiés puis remplacés par différents restes de façon que l'activité soit modifiée.
Cahoon Edgar
Lindqvist Ylva
Schneider Gunther
Shanklin John
Brookhaven Science Associates Llc
Goudreau Gage Dubuc
Karolinska Innovations Ab
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