Modified adamts4 molecules and method of use thereof

Details Modified adamts4 molecules and method of use thereof Modified adamts4 molecules and method of use thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2492444

The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of antiADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.

La présente invention concerne des protéines ADAMTS4 modifiées présentant une plus grande stabilité par rapport aux protéines non modifiées natives correspondantes. Ces protéines ADAMTS4 modifiées peuvent être exprimées et isolées en grandes quantités, ce qui permet de poursuivre la caractérisation des protéines consistant notamment à réaliser des études cinétiques enzymatiques et cristallographiques. Les protéines stables purifiées permettent également de faciliter la production d'anticorps anti-ADAMTS et le développement d'inhibiteurs d'enzymes ADAMTS.

Affiliated with

Also associated with

Rating

Modified adamts4 molecules and method of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified adamts4 molecules and method of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified adamts4 molecules and method of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2060317