Modified adenoviral fiber and target adenoviruses

Details Modified adenoviral fiber and target adenoviruses Modified adenoviral fiber and target adenoviruses

C - Chemistry, Metallurgy

07

K

C07K 14/075 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/34 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2285565

The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.

La présente invention a pour objet une fibre d'un adénovirus modifiée par mutation d'un ou plusieurs residus, lesdits résidus étant dirigés vers le récepteur cellulaire naturel dudit adénovirus au niveau de la structure tridimensionnelle. Elle concerne également un fragment d'ADN, un vecteur d'expression ainsi qu'une lignée cellulaire exprimant ladite fibre. Enfin, elle a trait à un adénovirus la comprenant, le procédé pour produire un tel adénovirus et une cellule hôte infectable ainsi qu'à leur usage thérapeutique et une composition pharmaceutique correspondante.

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