Modified adenoviral vectors for use in vaccines and gene...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 38/57 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/81 (2006.01) C12N 5/22 (2006.01) C12N 15/861 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2499385

The present invention provides novel methods and means for influencing the CTL- sensitivity of antigen presenting cells such as dendritic cells upon viral infections. The invention provides novel gene delivery vehicles that are useful in different therapeutic settings such as vaccination and/or gene therapy.

La présente invention concerne de nouveaux procédés et moyens pour influencer la sensibilité aux lymphocytes T cytotoxiques de cellules de présentant de l'antigène telles que des cellules dendritiques, au cours d'infections virales. L'invention a également pour objet de nouveaux excipients d'administration génique qui ont différentes utilités thérapeutiques telles que la vaccination et/ou la thérapie génique.

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