C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A01N 43/04 (2006.01) A01N 63/00 (2006.01) A61K 35/76 (2006.01) C12N 7/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2321135
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell- binding protein while maintaining the native trimeric protein biosynthesis profile. The present invention further provides means to specifically target particular cell types for infection with recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein.
La présente invention concerne un moyen permettant de modifier par des procédés génétiques le tropisme de vecteurs adénoviraux recombinants afin de transformer la protéine fibrillaire adénovirale se fixant sur la cellule tout en préservant le profil de biosynthèse natif de la protéine trimérique. L'invention concerne en outre un moyen permettant de cibler de façon spécifique des types de cellule particuliers qui seront infectés par des vecteurs adénoviraux recombinants selon des procédés génétiques afin de modifier la protéine fibrillaire adénovirale se fixant sur la cellule.
Curiel David T.
Krasnykh Victor N.
Borden Ladner Gervais Llp
Uab Research Foundation
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