C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2070682
2070682 9207003 PCTABS00012 The invention relates to a method for preventing the interaction of growth factors or cytokines with their specific cell receptors in mammals. The method comprises administering to the mammal a therapeutic amount of a chemically modified .alpha.2-macroglobulin having the ability to form a .alpha.2-macroglobulin-growth factor or -cytokine complex with a given growth factor or cytokine. The complex preferentially undergoes recepto-medicated modification, preferably endocytosis by .alpha.2-macroglobulin receptors, thereby reducing the availability of the active growth factor or cytokine to its specific cell surface receptor. The complexes are particularly useful in the treatment of endotoxic or septic shock through the scavenging of TNF-.alpha..
Gonias Steven L.
Hayes Anthony
Lamarre Jonathan
Wollenberg Gordon K.
Schumacher Lynn C.
University Of Guelph
University Of Virginia Alumni Patents Foundation (the)
LandOfFree
Modified.alpha.2-macroglobulins and their use as scavengers... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified.alpha.2-macroglobulins and their use as scavengers..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified.alpha.2-macroglobulins and their use as scavengers... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1676717