C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61K 31/513 (2006.01) A61K 31/551 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) C07D 211/58 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07K 5/065 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2361939
The present invention relates to modified amino-acid amides of general formula (I), wherein A, R, R1, R2, X1, X2, X3 and Y are defined as in Claim 1. The invention also relates to the tautomeric derivatives, diastereomers, enantiomers, mixtures and salts thereof, especially the physiologically compatible salts thereof with inorganic or organic acids or bases, whereby said acids and bases are provided with CGRP-antagonistic activity. The invention further relates to medicaments containing said compounds, to the use thereof and to a method for producing the same. The invention also relates to the use of said medicaments for producing and purifying antibodies and to the use thereof as labelled compounds in RIA and ELISA assays and as diagnostic or analytic auxiliaries in neurotransmitter research.
La présente invention concerne des amides d'aminoacides modifiés de formule générale (I), dans laquelle A, R, R?1¿, R?2¿, X?1¿, X?2¿, X?3¿ et Y correspondent à la définition donnée dans la revendication 1, leurs tautomères, leurs diastéromères, leurs énantiomères, leurs mélanges et leurs sels, en particulier leurs sels physiologiquement tolérés avec des acides ou des bases inorganiques ou organiques ayant des effets antagonistes de la CGRP. L'invention concerne également des produits pharmaceutiques contenant ces composés, leur utilisation et leur procédé de fabrication ainsi que leur utilisation pour la production et la purification d'anticorps, en tant que composés marqués dans les dosages RIA et ELISA et en tant que moyens de diagnostic ou d'analyse dans la recherche sur les neurotransmetteurs.
Doods Henri
Eberlein Wolfgang
Engel Wolfhard
Hallermayer Gerhard
Rudolf Klaus
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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