Modified annexin proteins and methods for their use in organ...

Details Modified annexin proteins and methods for their use in organ... Modified annexin proteins and methods for their use in organ...

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2628558

Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post- ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.

L'invention concerne des protéines d'annexine modifiée, contenant un homodimère d'annexine humaine V. L'invention concerne également des procédés d'utilisation de ces protéines, notamment en vue de prévenir la thrombose sans augmenter l'hémorragie et d'atténuer une lésion d'ischémie-reperfusion. Les annexines modifiées lient la phosphatidylsérine sur des surfaces cellulaires, évitant ainsi l'assemblage du complexe prothromkinase. L'annexine modifiée réduit la liaison de leucocytes et de plaquettes durant la reperfusion post-ischémique, rétablissant ainsi le flux sanguin microvasculaire et réduisant les lésions organiques.

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