Modified anti-egfr antibodies with reduced immunogenicity

Details Modified anti-egfr antibodies with reduced immunogenicity Modified anti-egfr antibodies with reduced immunogenicity

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) G06F 19/16 (2011.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2438513

The present invention relates to antibodies which are directed to the EGF receptor (HER1) to be administered especially to humans and in particular for therapeutic use in tumors. The antibodies are modified whereby the modification results in a reduced propensity for the antibody to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of anti-EGFR antibody 425 in its different forms and fragments thereof to result in Mab 425 variants that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

L'invention concerne des anticorps dirigés vers le récepteur EGF (HER1) afin d'être administrés aux humains en particulier et tout spécialement pour une utilisation thérapeutique sur les tumeurs. Les anticorps sont modifiés, ainsi la modification a pour conséquence une propension réduite pour l'anticorps à choisir une réponse immune, lors de l'administration à un sujet humain. Cette invention concerne en particulier la modification de l'anticorps anti-EGFR 425 sous ses différentes formes et les fragments de celui-ci pour produire des variants Mab 425 qui sont essentiellement non-immunogènes ou moins immunogènes que toute contrepartie non-modifiée lors d'une utilisation in vivo.

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