Modified anti-tnf alpha antibody

Details Modified anti-tnf alpha antibody Modified anti-tnf alpha antibody

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 7/08 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2466592

The invention relates to the modification of antibodies reactive to human tumor necrosis factor alpha (TNF alpha) to result in anti-TNF alpha antibodies that are substantially non-immunogenic or less immunogenic than any non- modified parental antibody when used in vivo. The invention relates also to peptide molecules comprising T-cell epitopes of the V-regions of the parental antibody which are modified by amino acid alteration in order to reduce or eliminate said T-cell epitopes.

L'invention concerne la modification d'anticorps réactifs au facteur de nécrose tumorale alpha (TNF alpha) en vue d'obtenir des anticorps anti-TNF-alpha sensiblement non immunogènes ou moins immunogènes que n'importe quel anticorps parental non modifié lorsqu'il est utilisé <i>in vivo</i>. L'invention concerne également des molécules peptidiques comprenant des épithopes de lymphocytes T des zones V de l'anticorps parental modifiées par altération amino acide en vue de réduire ou d'éliminer les épithopes de lymphocytes T.

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