Modified antibodies and methods of use

Details Modified antibodies and methods of use Modified antibodies and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2436092

Novel compounds, compositions and methods comprising modified antibodies are provided. In preferred embodiments the disclosed modified antibodies comprise antibodies having one or more of the constant region domains altered or deleted to afford beneficial physiological properties such as enhanced target localization and rapid blood clearance. The disclosed compounds are particularly useful for the treatment of neoplastic disorders in myelosuppressed patients.

L'invention concerne des composés, des compositions et des procédés dans lesquels interviennent des anticorps modifiés. En mode de réalisation préféré, les anticorps en question sont des anticorps à modification ou suppression d'un ou plusieurs domaines de région constante, ce qui permet d'offrir des propriétés physiologiques bénéfiques (par exemple, localisation de cible améliorée et clairance rapide du sang). Les composés décrits sont particulièrement utiles pour le traitement de troubles néoplasiques chez des patients en myélosuppression.

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