Modified antibodies stably produced in milk and methods of...

Details Modified antibodies stably produced in milk and methods of... Modified antibodies stably produced in milk and methods of...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C07K 16/04 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2506629

The invention features methods of producing an antibody in the milk of a transgenic mammal. The methods include providing a transgenic mammal whose somatic and germ cells comprise a sequence encoding an exogenous heavy chain variable region or antigen binding fragment thereof, at least one heavy chain constant region, or a fragment thereof, and a hinge region, operably linked to a promoter which directs expression in mammary epithelial cells, wherein said hinge region has been altered from the hinge region normally associated with the heavy chain constant region. The invention also features transgenic mammals, methods of producing these mammals, compositions comprising such antibodies, and nucleic acids encoding the antibodies.

L'invention concerne des procédés de production d'anticorps dans le lait de mammifère transgénique. Il s'agit de fournir un mammifère transgénique dont les cellules somatiques et germinales renferment une séquence codant une région variable à chaîne lourde exogène ou un fragment de liaison d'antigène correspondant, au moins une région constante à chaîne lourde, ou un fragment correspondant, et une région charnière, reliée opérationnelle à un promoteur qui conduit l'expression l'expression dans les cellules épithéliales mammaires. La région charnière a été modifiée par rapport à la région charnière normalement associée à la région constante à chaîne lourde. L'invention concerne également des mammifères transgéniques, des procédés de production correspondants, des compositions renfermant les anticorps considérés, et des acides nucléiques codant lesdits anticorps.

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