Modified antibodies with controlled clearance time

Details Modified antibodies with controlled clearance time Modified antibodies with controlled clearance time

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 1/107 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2090700

Modified antibodies are disclosed which have been modified by chemical conjugation with a heterobifunctional reagent, such as SPDP. The use of these modified antibodies in the preparation of compositions for the diagnosis and therapy of cancer and other mammalian disease is also disclosed. These diagnostic uses include immunoscintography. The modified antibodies can be further conjugated with labels or biologically active molecules for use in such diagnosis and therapy.

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