Modified antibody fragments

Details Modified antibody fragments Modified antibody fragments

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2527003

The present invention provides an antibody Fab or Fab' fragment to which at least one effector molecule is attached characterized in that the heavy chain in the fragment is not covalently bonded to the light chain and both the interchain cysteine of CL and the interchain cysteine of CH1 have been replaced with another amino acid.

L'invention concerne un fragment d'anticorps Fab ou Fab' sur lequel est fixée au moins une molécule effectrice, et caractérisé en ce que la chaîne lourde du fragment ne présente pas de liaison covalente avec la chaîne légère, et en ce que la cystéine interchaîne de C<SB>L</SB> et la cystéine interchaîne de C<SB>H</SB>1 ont toutes deux été remplacées par un acide aminé différent.

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